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Cardiovascular
VALSATAS-S 50 TAB
SALT COMPOSITION
VALSARTAN 24MG + SACUBITRIL 26MGTYPE
TABLET
STORAGE
Store VALSATAS-S 50 TAB below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children and pets.
PRODUCT INTRODUCTION
VALSATAS-S 50 TAB is a cutting-edge medication specifically designed for the management of chronic heart failure with reduced ejection fraction. This innovative tablet combines Valsartan, an angiotensin receptor blocker (ARB), with Sacubitril, a neprilysin inhibitor, to offer a dual-action approach. It works by relaxing blood vessels, reducing the workload on the heart, and enhancing the body's natural protective neurohormonal systems. VALSATAS-S 50 TAB is a crucial treatment option aimed at improving symptoms, quality of life, and reducing the risk of cardiovascular death and heart failure hospitalizations in adult patients. Always consult your doctor for proper diagnosis and prescription.
Uses of VALSATAS-S 50 TAB
VALSATAS-S 50 TAB is primarily used for the following condition:
- Chronic Heart Failure
VALSATAS-S 50 TAB is indicated for the treatment of symptomatic chronic heart failure with reduced ejection fraction in adult patients. It helps to reduce the risk of cardiovascular death and hospitalization for heart failure. By improving the heart's pumping efficiency and reducing fluid buildup, it alleviates symptoms like shortness of breath, fatigue, and swelling, significantly enhancing the patient's overall well-being and prognosis.
- Post-Myocardial Infarction Heart Failure
While primarily for chronic heart failure, its components have roles in post-myocardial infarction settings. The combination helps in managing the progression of heart failure that may develop after a heart attack, by improving cardiac function and preventing further damage. It contributes to better long-term outcomes for patients with compromised heart function following an ischemic event, under strict medical supervision.
- Hypertension (Off-label)
Although not its primary indication, the Valsartan component is an effective antihypertensive. In some cases, where heart failure is accompanied by high blood pressure, VALSATAS-S 50 TAB may also contribute to blood pressure control. However, its use is specifically tailored for heart failure management, and any use for hypertension alone would be considered off-label and should only be under the guidance of a specialist.
Side Effects of VALSATAS-S 50 TAB
Like all medications, VALSATAS-S 50 TAB can cause side effects, although not everybody gets them. Most side effects are mild to moderate and temporary. If any of these side effects bother you or do not go away, consult your doctor.
Common side effects
- Low blood pressure (hypotension)
- High potassium levels (hyperkalemia)
- Kidney problems (renal impairment)
- Dizziness
- Cough
Less common or rare side effects may occur and require immediate medical attention:
- Angioedema (swelling of face, lips, tongue, or throat)
- Severe allergic reactions
- Liver problems
If you experience any severe or persistent side effects, or symptoms of an allergic reaction, seek immediate medical advice. Do not stop taking the medication without consulting your doctor.
How to use VALSATAS-S 50 TAB
- Adults:
The recommended starting dose of VALSATAS-S 50 TAB is one tablet orally twice daily. The dose may be doubled at 2-4 week intervals based on patient tolerability and clinical response, up to a maximum target dose, as advised by your physician. It can be taken with or without food. Swallow the tablet whole with water; do not crush or chew.
- Children:
The safety and efficacy of VALSATAS-S 50 TAB in pediatric patients (below 18 years of age) have not been established. Therefore, it is generally not recommended for use in children unless specifically advised by a pediatric cardiologist in rare, specific circumstances.
- Elderly:
No specific dose adjustment is required for elderly patients based on age alone. However, caution should be exercised due to the higher likelihood of renal impairment or other comorbidities in this population. Close monitoring of blood pressure, renal function, and electrolytes is recommended.
- Missed Dose:
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this can increase the risk of side effects. Consult your doctor if you are unsure.
How VALSATAS-S 50 TAB works
VALSATAS-S 50 TAB exerts its therapeutic effects through a synergistic mechanism. Valsartan, an angiotensin II receptor blocker, selectively inhibits the binding of angiotensin II to the AT1 receptor. This action blocks the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to vasodilation, reduced blood pressure, and decreased fluid retention, thereby lowering the cardiac workload and improving heart function. Sacubitril, on the other hand, is a neprilysin inhibitor. Neprilysin is an enzyme responsible for the degradation of beneficial natriuretic peptides (NPs), bradykinin, and other vasoactive peptides. By inhibiting neprilysin, Sacubitril increases the levels of these endogenous peptides, leading to vasodilation, natriuresis (sodium excretion), diuresis (water excretion), and inhibition of pathological remodeling of the heart. The combined action of Valsartan and Sacubitril in VALSATAS-S 50 TAB provides comprehensive cardiovascular benefits, addressing multiple pathways involved in heart failure progression.
Precautions
- Do not use VALSATAS-S 50 TAB if you are allergic to Valsartan, Sacubitril, or any other ingredients.
- Avoid use if you have a history of angioedema related to previous ACE inhibitor or ARB therapy.
- Not recommended during pregnancy due to potential harm to the fetus.
- Use with caution in patients with severe renal impairment or severe hepatic impairment.
- Monitor blood pressure regularly, especially during initiation and dose titration, due to the risk of symptomatic hypotension.
- Monitor serum potassium levels, as hyperkalemia can occur, particularly in patients with renal impairment or those taking potassium-sparing diuretics.
Safety Advice
Alcohol
CAUTIONConsuming alcohol while taking VALSATAS-S 50 TAB may increase the risk of dizziness or lightheadedness due to its blood pressure-lowering effects. It is advisable to limit or avoid alcohol intake and consult your doctor.
Pregnancy
UNSAFEVALSATAS-S 50 TAB is not recommended during pregnancy as it can cause harm to the developing fetus. If you are pregnant or planning to become pregnant, inform your doctor immediately. Effective contraception should be used by women of childbearing potential.
Breastfeeding
CONSULT YOUR DOCTORIt is unknown whether VALSATAS-S 50 TAB passes into breast milk. Due to the potential for adverse effects on a nursing infant, breastfeeding is not recommended while taking this medication. Consult your doctor for alternative feeding options or treatment.
Driving
CAUTIONVALSATAS-S 50 TAB may cause dizziness or lightheadedness, especially when starting treatment or increasing the dose. If you experience these symptoms, avoid driving or operating heavy machinery until you know how the medication affects you.
Kidney
CAUTIONVALSATAS-S 50 TAB should be used with caution in patients with kidney disease. Your doctor will monitor your kidney function closely, especially during the initial phase of treatment and with dose adjustments, as it can affect renal parameters.
Liver
CAUTIONPatients with liver impairment should use VALSATAS-S 50 TAB with caution. Your doctor may adjust the dose or monitor liver function tests regularly to ensure safety and efficacy. Inform your doctor about any history of liver problems.
Fact Box
Frequently asked questions by patients
Q: Can VALSATAS-S 50 TAB be taken with other heart medications?
A: Yes, VALSATAS-S 50 TAB is often prescribed as part of a comprehensive treatment regimen for heart failure, which may include other cardiac medications. However, it should not be taken with ACE inhibitors due to increased risk of angioedema. Always inform your doctor about all medications you are taking to avoid potential interactions.
Q: How long does it take for VALSATAS-S 50 TAB to show results?
A: While some patients may feel an improvement in symptoms within a few weeks, the full benefits of VALSATAS-S 50 TAB in reducing cardiovascular events and improving heart function are typically observed over several months of consistent use. It's crucial to continue taking the medication as prescribed, even if you feel better.
Q: What should I do if my blood pressure drops too low?
A: If you experience symptoms of low blood pressure such as severe dizziness, lightheadedness, or fainting, lie down immediately and raise your feet. Contact your doctor or seek emergency medical attention. Your doctor may need to adjust your dose or other medications.
Q: Is VALSATAS-S 50 TAB a cure for heart failure?
A: VALSATAS-S 50 TAB is not a cure for heart failure, but it is a highly effective treatment that can significantly manage the condition, improve symptoms, enhance quality of life, and prolong life by reducing the risk of hospitalizations and cardiovascular death. It is a long-term management medication.
Frequently Asked Questions
Q: What is heart failure and how does VALSATAS-S 50 TAB help?
Heart failure is a chronic condition where the heart cannot pump enough blood to meet the body's needs. VALSATAS-S 50 TAB helps by relaxing blood vessels, reducing the strain on the heart, and promoting the excretion of excess fluid. This dual action improves the heart's pumping efficiency and reduces symptoms like breathlessness and swelling, thereby improving patient outcomes.
Q: Can I stop taking VALSATAS-S 50 TAB if I feel better?
No, you should never stop taking VALSATAS-S 50 TAB without consulting your doctor. Abruptly discontinuing the medication can lead to a worsening of your heart failure symptoms and increase the risk of serious cardiovascular events. Heart failure requires continuous management.
Q: What are the dietary restrictions while on this medication?
While there are no strict dietary restrictions, it is generally advisable to follow a low-sodium diet to help manage fluid retention and blood pressure, which complements the action of VALSATAS-S 50 TAB. Your doctor or a dietitian can provide personalized dietary advice. Avoid potassium-rich foods or supplements unless advised, due to the risk of hyperkalemia.
Q: How often do I need to get my blood tested while on VALSATAS-S 50 TAB?
Your doctor will likely recommend regular blood tests, especially during the initial phase of treatment and after any dose changes. These tests typically monitor kidney function (creatinine, eGFR) and electrolyte levels (especially potassium) to ensure the medication is well-tolerated and to detect any potential side effects early.
Q: What should I do if I experience swelling of my face or throat?
Swelling of the face, lips, tongue, or throat (angioedema) is a serious but rare side effect. If you experience any such symptoms, seek immediate medical attention. This could be a life-threatening allergic reaction, and you should stop taking the medication and inform your doctor or emergency services immediately.
Additional Information
VALSATAS-S 50 TAB represents a significant advancement in the management of chronic heart failure with reduced ejection fraction. By combining the benefits of an angiotensin receptor blocker and a neprilysin inhibitor, it offers a powerful and comprehensive approach to improve cardiac function, alleviate symptoms, and ultimately enhance the quality and duration of life for patients. It is crucial for patients to adhere strictly to their prescribed dosage and follow their doctor's advice, including regular monitoring of blood pressure and kidney function. Understanding the potential side effects and precautions associated with VALSATAS-S 50 TAB is vital for safe and effective treatment. Always maintain open communication with your healthcare provider regarding your health status and any concerns you may have, ensuring optimal management of your heart condition.
