T-GRELOR 90MG

Uses of T-GRELOR 90MG

T-GRELOR 90MG is primarily used to prevent serious cardiovascular events in patients at high risk. Its main applications include:

• History of Myocardial Infarction (MI)

  It is also used for the prevention of atherothrombotic events in patients with a history of myocardial infarction who are at high risk of developing a further atherothrombotic event. This helps to reduce the incidence of cardiovascular death, MI, and stroke in this vulnerable population, improving long-term prognosis.

• Prevention of Thrombotic Events

  Beyond ACS and MI, T-GRELOR 90MG is crucial in preventing other thrombotic events in patients with established atherosclerotic disease. By inhibiting platelet aggregation, it helps maintain blood flow, preventing the formation of clots that can lead to severe complications like ischemic stroke or systemic embolism, especially in conjunction with aspirin.

Side Effects of T-GRELOR 90MG

Like all medicines, T-GRELOR 90MG can cause side effects, although not everybody gets them. It's important to be aware of these and to consult your doctor if any become bothersome or severe.

While less common, some serious side effects may occur. Seek immediate medical attention if you experience:

Always discuss any concerns about side effects with your doctor or pharmacist. Do not stop taking T-GRELOR 90MG without consulting your healthcare provider.

How to use T-GRELOR 90MG

• Adults:

  The recommended initial loading dose of T-GRELOR 90MG is 180 mg (two 90 mg tablets) administered as a single dose. This should be followed by a maintenance dose of 90 mg twice daily. It is typically taken with a low dose of aspirin (usually 75-150 mg daily) as part of dual antiplatelet therapy. Always follow your doctor's instructions.

• Children:

  T-GRELOR 90MG is not recommended for use in children and adolescents below 18 years of age, as its safety and efficacy have not been established in this population. Consult a pediatrician for appropriate treatment options.

• Elderly:

  No dose adjustment is generally required for elderly patients. However, caution should be exercised due to the increased risk of bleeding in this population. Your doctor will assess your overall health and other medications before prescribing.

• Missed Dose:

  If you miss a dose of T-GRELOR 90MG, take your next dose at its regularly scheduled time. Do not take a double dose to make up for a missed one. Consistent dosing is important for maintaining its therapeutic effect.

How T-GRELOR 90MG works

Ticagrelor, the active ingredient in T-GRELOR 90MG, is a direct-acting, reversibly binding P2Y12 receptor antagonist. Unlike clopidogrel, ticagrelor does not require metabolic activation and exerts its antiplatelet effect directly. It selectively and reversibly binds to the P2Y12 receptor on the platelet surface, preventing adenosine diphosphate (ADP) from binding and activating the receptor. This inhibition leads to a reduction in ADP-mediated platelet activation and aggregation. By blocking the P2Y12 receptor, T-GRELOR 90MG effectively prevents the formation of blood clots, which are a primary cause of heart attacks and strokes in individuals with cardiovascular disease. Its reversible binding mechanism allows for a more rapid onset and offset of action compared to irreversible P2Y12 inhibitors. This unique pharmacological profile makes Ticagrelor a highly effective and important antiplatelet therapy in managing and preventing acute thrombotic events.

Precautions

• Increased risk of bleeding, especially in patients with active pathological bleeding or a history of intracranial hemorrhage.
• Use with caution in patients with moderate to severe hepatic impairment.
• Avoid concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) or strong CYP3A4 inducers (e.g., rifampicin, phenytoin).
• May cause dyspnea (shortness of breath), which is usually mild and transient but should be monitored.
• Not recommended for patients undergoing urgent coronary artery bypass grafting (CABG) unless the benefits outweigh the risks.
• Regular monitoring of kidney function may be advisable in some patients.

Safety Advice

Alcohol

CAUTION

Consuming alcohol while taking T-GRELOR 90MG may increase the risk of stomach bleeding. It is advisable to limit alcohol intake or consult your doctor regarding safe consumption levels.

Pregnancy

CONSULT YOUR DOCTOR

T-GRELOR 90MG is not recommended during pregnancy unless clearly necessary, as there is limited data on its effects. Your doctor will weigh the potential benefits against the risks to the fetus.

Breastfeeding

CONSULT YOUR DOCTOR

It is unknown whether Ticagrelor passes into breast milk. Therefore, breastfeeding is not recommended while taking T-GRELOR 90MG. Discuss with your doctor for alternatives or guidance.

Driving

SAFE

T-GRELOR 90MG is generally not known to impair your ability to drive or operate machinery. However, if you experience side effects like dizziness, avoid such activities until you feel well.

Kidney

CAUTION

Use T-GRELOR 90MG with caution in patients with severe kidney impairment. Dose adjustment may not be required, but close monitoring by your doctor is recommended.

Liver

CAUTION

T-GRELOR 90MG should be used with caution in patients with moderate to severe liver impairment, as it is primarily metabolized by the liver. Your doctor may adjust the dose or monitor you closely.

Fact Box

Frequently asked questions by patients

Frequently Asked Questions

Additional Information