Neurological

PREGABLEN-NTP TAB

Prescription Required

SALT COMPOSITION

TYPE

TABLET

STORAGE

Store PREGABLEN-NTP TAB below 25°C in a cool, dry place, away from direct sunlight and moisture. Keep it out of the reach and sight of children.

PRODUCT INTRODUCTION

PREGABLEN-NTP TAB is a combination medication specifically formulated to manage neuropathic pain, a type of chronic pain caused by nerve damage. This tablet combines Pregabalin, an anticonvulsant, with Nortriptyline, a tricyclic antidepressant, to provide comprehensive relief. It is particularly effective in addressing the burning, shooting, and tingling sensations associated with nerve pain, often improving quality of life for patients. The dual-action approach targets different pathways involved in pain transmission, offering enhanced efficacy compared to single-agent therapies. Always consult your doctor for proper diagnosis and dosage.

Uses of PREGABLEN-NTP TAB

PREGABLEN-NTP TAB is primarily used for the treatment and management of various neuropathic pain conditions.

Neuropathic Pain
This medication is highly effective in treating chronic neuropathic pain, which arises from damage or dysfunction of the nervous system. Conditions like diabetic neuropathy, post-herpetic neuralgia (shingles pain), and spinal cord injury-related pain can be significantly alleviated. It helps reduce the burning, shooting, stabbing, and tingling sensations often associated with these conditions, improving patient comfort and daily functioning.
Fibromyalgia
PREGABLEN-NTP TAB may also be prescribed for fibromyalgia, a chronic condition characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, memory, and mood issues. The combination of Pregabalin and Nortriptyline helps in managing the diffuse pain and associated symptoms, contributing to better sleep patterns and overall well-being for individuals suffering from this complex disorder.
Anxiety and Depression (associated with chronic pain)
Nortriptyline, a component of PREGABLEN-NTP TAB, is a tricyclic antidepressant that also has pain-modulating properties. It helps in improving mood and reducing anxiety often associated with chronic pain conditions. By addressing the psychological aspects alongside the physical pain, this combination provides a more holistic approach to managing chronic pain, leading to better patient outcomes and improved mental health.

Side Effects of PREGABLEN-NTP TAB

Like all medicines, PREGABLEN-NTP TAB can cause side effects, although not everybody gets them. Most side effects are mild to moderate and temporary.

Common side effects

Dizziness
Drowsiness
Dry mouth
Constipation
Weight gain

Less common or rare side effects, though serious, require immediate medical attention.

Suicidal thoughts or behavior changes
Severe allergic reactions (rash, swelling, difficulty breathing)
Vision changes (blurred vision, double vision)
Heart rhythm disturbances

If any side effect bothers you or persists, please consult your doctor. Do not discontinue the medication without medical advice.

How to use PREGABLEN-NTP TAB

Adults:
The typical starting dose is one tablet once daily, preferably at bedtime, to minimize daytime drowsiness. The dosage may be gradually increased by your doctor based on your response and tolerability. It is crucial to follow your doctor's instructions precisely and not to alter the dose or stop the medication abruptly without consultation.
Children:
PREGABLEN-NTP TAB is generally not recommended for use in children and adolescents below 18 years of age, as its safety and efficacy in this age group have not been established. Pediatric use should only be considered under strict medical supervision and if deemed absolutely necessary by a specialist.
Elderly:
Elderly patients may be more sensitive to the effects of this medication, particularly side effects like dizziness, drowsiness, and anticholinergic effects. A lower starting dose and slower titration may be advised. Close monitoring for adverse effects and kidney function is recommended. Always consult your doctor for specific geriatric dosing.
Missed Dose:
If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to compensate for a missed one, as this can increase the risk of side effects.

How PREGABLEN-NTP TAB works

PREGABLEN-NTP TAB works through the synergistic actions of its two active ingredients. Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This binding modulates the release of several excitatory neurotransmitters, including glutamate, norepinephrine, and substance P, thereby reducing hyperexcitability of nerve cells responsible for pain signals. This action helps to calm overactive nerves and alleviate neuropathic pain symptoms.

Precautions

Do not stop taking this medicine suddenly, as it may lead to withdrawal symptoms.
Inform your doctor if you have a history of heart disease, glaucoma, or urinary retention.
Use with caution in patients with kidney impairment; dose adjustment may be necessary.
Monitor for changes in mood or behavior, especially suicidal thoughts, particularly at the start of treatment.
Avoid driving or operating heavy machinery until you know how this medicine affects you, due to potential dizziness and drowsiness.
Inform your doctor about all other medications you are taking, including herbal supplements, to avoid potential drug interactions.

Safety Advice

Alcohol

UNSAFE

Consumption of alcohol with PREGABLEN-NTP TAB is unsafe. It can increase the sedative effects of the medication, leading to excessive drowsiness, dizziness, and impaired judgment. Avoid alcohol during treatment.

Pregnancy

CONSULT YOUR DOCTOR

PREGABLEN-NTP TAB is not recommended during pregnancy unless clearly necessary and after careful consideration of risks and benefits by your doctor. Both components may pose risks to the developing fetus. Discuss potential risks and benefits with your healthcare provider.

Breastfeeding

CONSULT YOUR DOCTOR

Both Pregabalin and Nortriptyline are excreted into breast milk and may affect the nursing infant. It is advisable to consult your doctor before using PREGABLEN-NTP TAB if you are breastfeeding. Your doctor will weigh the benefits against the potential risks.

Driving

UNSAFE

PREGABLEN-NTP TAB can cause dizziness, drowsiness, and blurred vision, which may impair your ability to drive or operate machinery safely. It is advised to avoid such activities until you are certain how this medication affects you.

Kidney

CAUTION

Patients with kidney disease should use PREGABLEN-NTP TAB with caution. Pregabalin is primarily excreted by the kidneys, and dose adjustments may be necessary based on renal function. Regular monitoring of kidney function is recommended by your doctor.

Liver

CAUTION

Use PREGABLEN-NTP TAB with caution in patients with liver disease. Nortriptyline is metabolized in the liver, and impaired liver function may affect its clearance. Your doctor may need to adjust the dosage or monitor liver function tests regularly.

Fact Box

Chemical Class

GABA Analogue (Pregabalin), Tricyclic Antidepressant (Nortriptyline)

Habit Forming

Yes

Therapeutic Class

Neuropathic Pain, Antidepressant

Action Class

Alpha-2-delta Ligand, Norepinephrine-Serotonin Reuptake Inhibitor

Frequently asked questions by patients

Q: Can I stop taking PREGABLEN-NTP TAB if my pain improves?

A: No, you should not stop taking PREGABLEN-NTP TAB suddenly, even if your pain improves. Abrupt discontinuation can lead to withdrawal symptoms such as anxiety, insomnia, nausea, sweating, and seizures. Always consult your doctor, who will gradually reduce the dose over time.

Q: How long does it take for PREGABLEN-NTP TAB to show its effect?

A: The effects of PREGABLEN-NTP TAB may not be immediate. While some patients might experience relief within a few days, it often takes several weeks of consistent use to achieve the full therapeutic benefits, especially for chronic neuropathic pain and mood improvement. Patience and adherence to the prescribed regimen are key.

Q: Will PREGABLEN-NTP TAB make me gain weight?

A: Weight gain is a known potential side effect of both Pregabalin and Nortriptyline. It's important to monitor your diet and engage in regular physical activity while on this medication. If you are concerned about weight gain, discuss it with your doctor, who can offer advice or consider alternatives.

Q: Is PREGABLEN-NTP TAB safe for long-term use?

A: PREGABLEN-NTP TAB can be used for long-term management of chronic neuropathic pain under strict medical supervision. Your doctor will regularly assess your condition, monitor for side effects, and adjust the treatment as needed to ensure its continued safety and effectiveness. Do not self-medicate for extended periods.

Frequently Asked Questions

Q: What should I do if I experience severe side effects?

If you experience any severe side effects such as severe allergic reactions (rash, swelling of face/throat, difficulty breathing), suicidal thoughts, or significant changes in vision, seek immediate medical attention. Do not delay in contacting emergency services or your healthcare provider.

Q: Can PREGABLEN-NTP TAB be taken with other pain relievers?

Combining PREGABLEN-NTP TAB with other pain relievers, especially those that cause drowsiness or affect the central nervous system, should be done with caution and under medical guidance. Always inform your doctor about all other medications, including over-the-counter pain relievers, to prevent potential interactions.

Q: Does PREGABLEN-NTP TAB affect fertility?

There is limited data specifically on the effects of PREGABLEN-NTP TAB on human fertility. Animal studies with high doses of Pregabalin have shown some effects on male fertility. If you have concerns about fertility while on this medication, it is best to discuss them with your doctor.

Q: What dietary restrictions should I follow while taking this medicine?

Generally, there are no specific dietary restrictions with PREGABLEN-NTP TAB, other than avoiding alcohol. However, maintaining a balanced diet can help manage potential side effects like weight gain. Always follow your doctor's advice regarding diet and lifestyle changes during treatment.

Q: Is PREGABLEN-NTP TAB addictive?

Pregabalin, one of the components, has a potential for abuse and dependence, especially at higher doses or in individuals with a history of substance abuse. It is important to take this medication exactly as prescribed by your doctor and not to exceed the recommended dosage. Do not share this medication with others.