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Neurological
MINODIP TAB
SALT COMPOSITION
NIMODIPINE TAB BP 30 MGTYPE
TABLET
STORAGE
Store MINODIP TAB below 25°C in a dry place, protected from direct light and moisture. Keep it in its original packaging to maintain efficacy and out of reach of children and pets.
PRODUCT INTRODUCTION
MINODIP TAB, containing Nimodipine BP 30 mg, is a crucial medication primarily used in the management of subarachnoid hemorrhage (SAH). This potent calcium channel blocker is specifically designed to prevent and treat cerebral vasospasm, a serious complication that can occur after SAH and lead to delayed cerebral ischemia. By improving cerebral blood flow, MINODIP TAB helps to protect brain tissue and enhance neurological recovery. It is a vital component in the acute care of patients experiencing this life-threatening condition, ensuring better outcomes and reducing the risk of severe neurological deficits.
Uses of MINODIP TAB
MINODIP TAB is primarily indicated for the prevention and treatment of neurological deficits due to ischemic neurological impairment caused by cerebral vasospasm following subarachnoid hemorrhage (SAH).
- Subarachnoid Hemorrhage (SAH) Management
MINODIP TAB is crucial for patients who have experienced a subarachnoid hemorrhage, a type of stroke caused by bleeding on the surface of the brain. It helps in managing the acute phase by preventing complications that can arise from the initial bleed, thereby supporting the overall recovery process and reducing the severity of potential neurological damage.
- Prevention of Cerebral Vasospasm
Following a subarachnoid hemorrhage, there is a significant risk of cerebral vasospasm, where blood vessels in the brain narrow, restricting blood flow. MINODIP TAB specifically targets this complication, working to relax these constricted vessels and ensure adequate blood supply to the brain, which is vital for preventing delayed cerebral ischemia and subsequent neurological deterioration.
- Improvement of Neurological Outcome
By effectively preventing and treating cerebral vasospasm, MINODIP TAB plays a pivotal role in improving the overall neurological outcome for patients recovering from subarachnoid hemorrhage. It helps to preserve brain function, minimize long-term neurological deficits, and enhance the chances of a more complete recovery, contributing significantly to patient quality of life post-SAH.
Side Effects of MINODIP TAB
Like all medicines, MINODIP TAB can cause side effects, although not everybody gets them. Most side effects are mild and temporary, but some can be serious.
Common side effects
- Headache
- Dizziness
- Nausea
- Flushing
- Hypotension (low blood pressure)
Less commonly, or in sensitive individuals, more severe reactions may occur. Seek immediate medical attention if you experience any of these rare but serious side effects.
- Bradycardia (slow heart rate)
- Liver enzyme elevation
- Allergic reactions (rash, itching, swelling)
- Gastrointestinal discomfort (abdominal pain, diarrhea)
- Thrombocytopenia (low platelet count)
If any side effect bothers you or persists, please consult your doctor. Do not stop taking the medication without medical advice.
How to use MINODIP TAB
- Adults:
The usual recommended oral dosage for adults is 60 mg (two MINODIP TABs) every 4 hours for 21 consecutive days, starting within 96 hours of the subarachnoid hemorrhage. It should be taken on an empty stomach, at least one hour before or two hours after a meal.
- Children:
The safety and efficacy of Nimodipine in pediatric patients have not been established. Its use in children is generally not recommended unless specifically advised and closely monitored by a specialist in critical care settings.
- Elderly:
No specific dose adjustment is typically required for elderly patients, but caution should be exercised due to a potentially increased risk of hypotension. Blood pressure should be monitored regularly, and dosage may be adjusted based on individual response and tolerability.
- Missed Dose:
If a dose of MINODIP TAB is missed, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
How MINODIP TAB works
Nimodipine, the active ingredient in MINODIP TAB, is a dihydropyridine calcium channel blocker with a high affinity for cerebral blood vessels. Its primary mechanism involves inhibiting the influx of calcium ions into vascular smooth muscle cells, particularly in the cerebral arteries. This action leads to relaxation of the smooth muscle, resulting in vasodilation and an increase in cerebral blood flow. In the context of subarachnoid hemorrhage, Nimodipine prevents the constriction of blood vessels (vasospasm) that often occurs due to the presence of blood in the subarachnoid space. By mitigating vasospasm, MINODIP TAB helps to maintain adequate oxygen and nutrient supply to brain tissues, thereby preventing delayed cerebral ischemia and improving neurological outcomes. Its selective action on cerebral vasculature minimizes systemic hypotensive effects compared to other calcium channel blockers.
Precautions
- Monitor blood pressure regularly, especially at the start of treatment.
- Use with caution in patients with severe liver impairment, as dosage adjustment may be necessary.
- Avoid concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) or inducers (e.g., rifampicin, phenytoin).
- Grapefruit juice can increase Nimodipine levels; avoid consumption during treatment.
- Patients with unstable angina or recent myocardial infarction should be monitored closely.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
Safety Advice
Alcohol
CAUTIONConsumption of alcohol with MINODIP TAB may increase the risk of dizziness and hypotension. It is advisable to limit or avoid alcohol intake during your treatment period to prevent adverse effects.
Pregnancy
CONSULT YOUR DOCTORMINODIP TAB is generally not recommended during pregnancy unless clearly necessary and the potential benefits outweigh the risks. Always consult your doctor to discuss the risks and benefits before taking this medication if you are pregnant or planning a pregnancy.
Breastfeeding
CONSULT YOUR DOCTORNimodipine is known to be excreted in human milk. Therefore, breastfeeding is generally not advised while taking MINODIP TAB. Consult your healthcare provider to weigh the benefits of treatment against the risks to the infant.
Driving
CAUTIONMINODIP TAB may cause dizziness or lightheadedness, especially at the beginning of treatment or when the dose is adjusted. If you experience these symptoms, avoid driving or operating heavy machinery until you know how the medication affects you.
Kidney
CONSULT YOUR DOCTORPatients with severe kidney impairment should use MINODIP TAB with caution. Your doctor may need to monitor your kidney function closely or adjust the dosage to prevent accumulation of the drug and potential side effects.
Liver
CAUTIONMINODIP TAB is metabolized in the liver. Patients with impaired liver function may have increased drug levels, leading to enhanced effects or side effects. Close monitoring and potential dose reduction are necessary under medical supervision.
Fact Box
Frequently asked questions by patients
Q: What is MINODIP TAB used for?
A: MINODIP TAB is primarily used to prevent and treat cerebral vasospasm, a narrowing of blood vessels in the brain, which can occur after a subarachnoid hemorrhage (bleeding on the brain's surface). It helps improve blood flow to the brain and reduce neurological damage.
Q: How should I take MINODIP TAB?
A: You should take MINODIP TAB exactly as prescribed by your doctor, usually 60 mg every 4 hours for 21 days. It is recommended to take it on an empty stomach, at least one hour before or two hours after a meal, to ensure optimal absorption.
Q: Can MINODIP TAB cause low blood pressure?
A: Yes, MINODIP TAB can cause a drop in blood pressure (hypotension) as a common side effect, especially when you first start taking it. Your doctor will monitor your blood pressure regularly to ensure it remains within a safe range.
Q: What should I avoid while taking MINODIP TAB?
A: It's important to avoid grapefruit juice as it can increase the levels of Nimodipine in your blood, potentially leading to more side effects. Also, inform your doctor about all other medications you are taking to avoid potential drug interactions.
Frequently Asked Questions
Q: Is MINODIP TAB a type of blood thinner?
No, MINODIP TAB is not a blood thinner. It is a calcium channel blocker that works by relaxing blood vessels in the brain to improve blood flow and prevent vasospasm after a subarachnoid hemorrhage. It does not directly affect blood clotting.
Q: How long do I need to take MINODIP TAB?
The typical duration of treatment with MINODIP TAB for subarachnoid hemorrhage is 21 consecutive days, starting within 96 hours of the hemorrhage. However, your doctor will determine the exact duration based on your specific condition and response to treatment.
Q: What if I experience dizziness after taking MINODIP TAB?
Dizziness is a common side effect of MINODIP TAB due to its effect on blood pressure. If you experience dizziness, sit or lie down until it passes. Avoid driving or operating machinery. If dizziness is severe or persistent, inform your doctor immediately.
Q: Can MINODIP TAB interact with other medications?
Yes, MINODIP TAB can interact with several medications, including other blood pressure medicines, certain antibiotics, antifungals, and anti-epileptic drugs. Always provide your doctor with a complete list of all medications, including over-the-counter drugs and herbal supplements, to prevent adverse interactions.
Q: Is MINODIP TAB safe for long-term use?
MINODIP TAB is typically prescribed for a specific duration (usually 21 days) following a subarachnoid hemorrhage. Its long-term use beyond this period for this indication is not standard. Any extended use would be under strict medical supervision for specific conditions, if at all.
Additional Information
MINODIP TAB, with its active ingredient Nimodipine, stands as a critical therapeutic agent in the complex management of subarachnoid hemorrhage (SAH). By effectively targeting and preventing cerebral vasospasm, it plays an indispensable role in safeguarding neurological function and improving patient outcomes following this severe cerebrovascular event. Its selective action on cerebral blood vessels underscores its importance in minimizing the devastating consequences of delayed cerebral ischemia. Patients prescribed MINODIP TAB should adhere strictly to their doctor's instructions regarding dosage and administration, and be vigilant about potential side effects. Regular monitoring and open communication with healthcare providers are paramount to ensure the safe and effective use of this medication. MINODIP TAB represents a significant advancement in neurocritical care, offering hope for enhanced recovery and reduced long-term disability for individuals affected by SAH.
