NITROFURAN-100 TAB

Uses of NITROFURAN-100 TAB

NITROFURAN-100 TAB is prescribed for the treatment and prevention of bacterial infections affecting the urinary tract.

• Prophylaxis of Recurrent UTIs

  For individuals prone to recurrent urinary tract infections, NITROFURAN-100 TAB can be prescribed at a lower dose for long-term prophylaxis. This helps prevent the re-establishment of bacterial colonies in the urinary system, significantly reducing the frequency of infection episodes and improving quality of life.

• Post-Surgical UTI Prevention

  In certain surgical procedures involving the urinary tract, NITROFURAN-100 may be used to prevent post-operative bacterial infections. Administered before or after surgery, it ensures a sterile urinary environment, minimizing the risk of complications and promoting a smoother recovery.

Side Effects of NITROFURAN-100 TAB

Like all medications, NITROFURAN-100 TAB can cause side effects, although not everybody gets them. Most side effects are mild and temporary.

Serious side effects are rare but require immediate medical attention.

If any side effect persists or worsens, or if you experience any severe reactions, consult your doctor immediately. Do not stop taking the medication without consulting your physician.

How to use NITROFURAN-100 TAB

• Adults:

  The usual dosage for acute uncomplicated UTIs is 50-100 mg four times a day for 7 days. For prophylaxis, a lower dose of 50-100 mg once daily at bedtime may be prescribed. Always take with food to enhance absorption and reduce gastrointestinal upset.

• Children:

  Dosage should be determined by a pediatrician based on the child's weight and the severity of the infection. Typically, it is 5-7 mg/kg/day in four divided doses for acute infections. Long-term prophylaxis may involve 1 mg/kg/day in one or two divided doses.

• Elderly:

  Elderly patients may be more susceptible to side effects, especially pulmonary and hepatic reactions. A reduced dosage or careful monitoring may be required, particularly if renal function is impaired. Consult a doctor for personalized advice.

• Missed Dose:

  If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

How NITROFURAN-100 TAB works

Nitrofurantoin, the active component in NITROFURAN-100 TAB, exerts its antibacterial action primarily within the urinary tract. It is rapidly filtered by the kidneys and excreted into the urine, where it achieves high concentrations. Once inside bacterial cells, nitrofurantoin is reduced by bacterial flavoproteins to highly reactive intermediates. These intermediates are potent electrophiles that damage multiple bacterial macromolecules, including DNA, RNA, proteins, and cell wall components. This widespread damage disrupts vital bacterial metabolic processes, ultimately leading to bacterial cell death. Unlike many other antibiotics, nitrofurantoin's mechanism of action is complex and involves multiple targets, which reduces the likelihood of bacterial resistance development. Its unique mode of action makes it particularly effective against common uropathogens like E. coli. The drug's activity is largely bacteriostatic at lower concentrations and bactericidal at higher concentrations, ensuring effective eradication of the infection within the urinary system.

Precautions

• Do not use if you have severe kidney disease (creatinine clearance less than 60 mL/min).
• Avoid use in pregnant women at term (38-42 weeks gestation) or during labor and delivery due to risk of hemolytic anemia in the neonate.
• Use with caution in patients with G6PD deficiency, as it can cause hemolytic anemia.
• Discontinue treatment if signs of peripheral neuropathy (tingling, numbness) occur.
• Monitor liver function tests periodically, especially during long-term therapy.
• May cause false-positive results for glucose in the urine when using Benedict's or Fehling's solution.
• Inform your doctor about all other medications you are taking to avoid potential drug interactions.

Safety Advice

Alcohol

CAUTION

Consuming alcohol while taking NITROFURAN-100 TAB may increase the risk of certain side effects like dizziness and nausea. It's advisable to limit or avoid alcohol intake during treatment to ensure optimal recovery.

Pregnancy

CONSULT YOUR DOCTOR

NITROFURAN-100 TAB should be used during pregnancy only if clearly needed and prescribed by a doctor, especially avoiding use near term due to potential risks to the newborn. Always discuss the benefits and risks with your healthcare provider.

Breastfeeding

CONSULT YOUR DOCTOR

Small amounts of Nitrofurantoin may pass into breast milk. It is important to consult your doctor before breastfeeding while on this medication, especially if the infant has G6PD deficiency or is under one month old.

Driving

SAFE

NITROFURAN-100 TAB generally does not impair your ability to drive or operate machinery. However, if you experience dizziness or blurred vision, avoid such activities until you feel well.

Kidney

UNSAFE

NITROFURAN-100 TAB is contraindicated in patients with severe kidney impairment (creatinine clearance < 60 mL/min) as it can lead to toxic accumulation of the drug and reduced efficacy. Consult your doctor for alternative treatments.

Liver

CAUTION

Use NITROFURAN-100 TAB with caution if you have a history of liver disease. Rare cases of liver damage have been reported. Your doctor may monitor your liver function during treatment, especially with prolonged use.

Fact Box

Frequently asked questions by patients

Frequently Asked Questions

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