GRISOFUL-250 TAB

Uses of GRISOFUL-250 TAB

GRISOFUL-250 TAB is primarily used to treat various fungal infections caused by dermatophytes. It is effective for infections of the:

• Skin Infections (Tinea Corporis, Tinea Cruris)

  GRISOFUL-250 TAB is highly effective in treating ringworm (Tinea Corporis) and jock itch (Tinea Cruris). These infections manifest as red, itchy, circular rashes on the body and groin area, respectively. Griseofulvin works by integrating into newly formed skin cells, making them resistant to fungal growth, thereby clearing the infection and alleviating symptoms like itching and redness over time. Consistent use as prescribed is vital for complete recovery.

• Hair and Scalp Infections (Tinea Capitis)

  This medication is a cornerstone in treating Tinea Capitis, a fungal infection of the scalp and hair follicles, commonly seen in children. Symptoms include scaly patches, hair loss, and sometimes inflammation. GRISOFUL-250 TAB works systemically to reach the hair follicles, where it inhibits fungal growth and allows healthy hair to regrow. Treatment duration can be several weeks to months, requiring patience and adherence for optimal results.

• Nail Infections (Onychomycosis)

  GRISOFUL-250 TAB is used for fungal infections of the fingernails and toenails (onychomycosis) caused by dermatophytes. These infections can cause nails to become discolored, thickened, and brittle. Griseofulvin is incorporated into the new nail growth, protecting it from fungal invasion as the infected part grows out and is trimmed away. Treatment for nail infections can be prolonged, often requiring several months, due to the slow growth rate of nails.

Side Effects of GRISOFUL-250 TAB

Like all medicines, GRISOFUL-250 TAB can cause side effects, although not everybody gets them. Most side effects are mild and temporary.

Less common but more serious side effects may occur. Seek immediate medical attention if you experience any of these:

If any side effect bothers you or persists, please consult your doctor. Do not stop the medication without medical advice.

How to use GRISOFUL-250 TAB

• Adults:

  The usual adult dosage for GRISOFUL-250 TAB is 250mg to 500mg daily, taken in a single dose or divided doses. For severe or difficult-to-treat infections, especially those of the nails, the dosage may be increased up to 1g daily. It should be taken with or after a fatty meal to enhance absorption. The duration of treatment varies depending on the site and severity of the infection: typically 2-4 weeks for skin, 4-8 weeks for hair/scalp, and 4-12 months or longer for nails.

• Children:

  For children, the recommended dosage is usually 10-20 mg/kg body weight per day, administered in a single dose or divided doses. It is crucial to consult a pediatrician for precise dosing based on the child's weight and the specific infection. As with adults, administration with a fatty meal is advised to improve absorption. Treatment duration will be determined by the doctor based on the clinical response.

• Elderly:

  Elderly patients may be more susceptible to side effects, particularly liver-related issues. While no specific dose adjustment is generally required solely based on age, a lower initial dose or closer monitoring may be considered, especially if there are pre-existing liver conditions or multiple co-medications. Always consult a doctor for personalized advice.

• Missed Dose:

  If you miss a dose of GRISOFUL-250 TAB, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this can increase the risk of side effects. Consult your doctor if you frequently miss doses or have concerns.

How GRISOFUL-250 TAB works

Griseofulvin, the active ingredient in GRISOFUL-250 TAB, works by interfering with fungal cell division and growth. After oral administration, it is absorbed and deposited in keratin precursor cells, which eventually form the keratinized tissues of the skin, hair, and nails. This unique mechanism allows Griseofulvin to bind tightly to keratin, making the new keratin resistant to fungal invasion. The medication exerts its fungistatic effect by disrupting the mitotic spindle structure of fungal cells, thereby inhibiting fungal mitosis (cell division). It also interferes with nucleic acid synthesis. As the infected keratinized tissues are shed and replaced by healthy, Griseofulvin-containing keratin, the fungal infection is gradually cleared. This systemic approach is particularly effective for deep-seated or widespread fungal infections that topical treatments may not reach.

Precautions

• Inform your doctor about any history of liver disease before starting this medication.
• Avoid alcohol consumption during treatment, as it can intensify side effects and cause a disulfiram-like reaction.
• GRISOFUL-250 TAB can cause photosensitivity; avoid prolonged sun exposure and use sunscreen/protective clothing.
• Regular monitoring of liver function tests may be required during prolonged therapy.
• This medication can reduce the effectiveness of oral contraceptives; use alternative birth control methods.
• Do not take if you are pregnant or planning to become pregnant, as it can cause birth defects.

Safety Advice

Alcohol

UNSAFE

Avoid alcohol consumption while taking GRISOFUL-250 TAB. Alcohol can increase the risk of side effects like nausea, vomiting, flushing, and headaches, and may also put additional strain on your liver.

Pregnancy

UNSAFE

GRISOFUL-250 TAB is considered unsafe during pregnancy as it has been shown to cause birth defects in animal studies. Women of childbearing potential should use effective contraception during treatment and for at least one month after the last dose.

Breastfeeding

CONSULT YOUR DOCTOR

It is not known whether Griseofulvin passes into breast milk. Therefore, it is advisable to consult your doctor before taking GRISOFUL-250 TAB if you are breastfeeding. Your doctor will weigh the benefits against the potential risks.

Driving

CAUTION

GRISOFUL-250 TAB may cause dizziness or lightheadedness in some individuals. If you experience these symptoms, avoid driving or operating heavy machinery until you know how the medication affects you.

Kidney

CONSULT YOUR DOCTOR

While Griseofulvin is primarily metabolized by the liver, caution is advised for patients with severe kidney impairment. It is important to discuss your kidney health with your doctor before starting GRISOFUL-250 TAB.

Liver

UNSAFE

GRISOFUL-250 TAB should be used with extreme caution or avoided in patients with pre-existing liver disease or impairment, as it can cause hepatotoxicity. Regular liver function monitoring is essential during prolonged treatment. Inform your doctor about any history of liver issues.

Fact Box

Frequently asked questions by patients

Frequently Asked Questions

Additional Information