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Antibiotics
CEFTRACEF 1GM INJ W/W
SALT COMPOSITION
CEFTRIAXONE 1GM WITH WATERTYPE
INJECTION
STORAGE
Store CEFTRACEF 1GM INJ W/W below 25°C. Protect from light and moisture. Do not freeze. Keep the vial in the outer carton until use. Reconstituted solutions should be used immediately or stored as per specific guidelines provided by your pharmacist.
PRODUCT INTRODUCTION
CEFTRACEF 1GM INJ W/W is a powerful injectable antibiotic widely used in India to combat a variety of severe bacterial infections. Containing Ceftriaxone 1GM, a third-generation cephalosporin, it is highly effective against a broad spectrum of Gram-positive and Gram-negative bacteria. This medication is typically prescribed for serious infections that require hospitalisation or intensive treatment, ensuring rapid and effective bacterial eradication. Its formulation with Water for Injection ensures ease of preparation and administration, making it a crucial tool in modern medical practice for both adults and children. Always consult a healthcare professional for proper diagnosis and treatment.
Uses of CEFTRACEF 1GM INJ W/W
CEFTRACEF 1GM INJ W/W is indicated for the treatment of various bacterial infections. It is crucial to use this medication only under the guidance of a registered medical practitioner.
- Respiratory Tract Infections
Effectively treats severe respiratory infections such as community-acquired pneumonia, hospital-acquired pneumonia, and bronchitis caused by susceptible bacteria. It helps clear the infection, reducing symptoms like cough, fever, and difficulty breathing, and preventing further complications.
- Urinary Tract Infections
Used for complicated urinary tract infections (UTIs) including pyelonephritis, where the infection has spread to the kidneys. Ceftriaxone targets the bacteria causing the infection, alleviating symptoms like painful urination, frequent urges, and flank pain, ensuring complete eradication.
- Skin and Soft Tissue Infections
Prescribed for serious skin and soft tissue infections, including cellulitis, erysipelas, and wound infections, especially those that are severe or have not responded to oral antibiotics. It helps to control the bacterial spread, promoting healing and preventing abscess formation.
Side Effects of CEFTRACEF 1GM INJ W/W
Like all medicines, CEFTRACEF 1GM INJ W/W can cause side effects, although not everybody gets them. Most side effects are mild and temporary, but some can be serious. Inform your doctor if any side effect bothers you or persists.
Common side effects
- Diarrhea
- Rash
- Pain or tenderness at the injection site
- Nausea
- Vomiting
Less common or rare side effects may occur and require immediate medical attention if experienced:
- Severe allergic reactions (anaphylaxis)
- Clostridium difficile-associated diarrhea (CDAD)
- Blood disorders (e.g., anemia, leukopenia)
- Gallbladder sludge or stones (pseudolithiasis)
- Kidney problems (e.g., interstitial nephritis)
If you experience any severe or persistent side effects, or if you notice any signs of an allergic reaction (e.g., swelling of face, lips, tongue, or throat, difficulty breathing), seek immediate medical help. Always discuss your medical history with your doctor before starting this medication.
How to use CEFTRACEF 1GM INJ W/W
- Adults:
The usual adult dosage is 1 to 2 grams administered once daily (every 24 hours) either intravenously (IV) or intramuscularly (IM). In severe cases or infections caused by moderately susceptible organisms, the total daily dose may be increased to 4 grams, given as a single dose or in two divided doses.
- Children:
For pediatric patients, the recommended daily dose is 50 to 75 mg/kg body weight, administered once daily (every 24 hours) by IV or IM route. The total daily dose should not exceed 2 grams. For meningitis, a loading dose of 100 mg/kg (not to exceed 4 grams) may be given, followed by 100 mg/kg/day.
- Elderly:
No specific dose adjustment is generally required for elderly patients unless there is severe renal or hepatic impairment. However, caution should be exercised, and renal function should be monitored, as elderly patients may have reduced physiological function.
- Missed Dose:
If a dose of CEFTRACEF 1GM INJ W/W is missed, it should be administered as soon as remembered. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to catch up.
How CEFTRACEF 1GM INJ W/W works
Ceftriaxone, the active ingredient in CEFTRACEF 1GM INJ W/W, exerts its bactericidal action by inhibiting bacterial cell wall synthesis. It achieves this by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall. These PBPs are crucial enzymes involved in the final stages of peptidoglycan synthesis, which is essential for maintaining the structural integrity of the bacterial cell wall. By interfering with these enzymes, Ceftriaxone prevents the cross-linking of peptidoglycan units, leading to a weakened and defective cell wall. This compromised cell wall makes the bacteria susceptible to osmotic lysis, ultimately resulting in bacterial death. Ceftriaxone's broad-spectrum activity stems from its ability to penetrate various bacterial membranes and its high affinity for the PBPs of many clinically significant pathogens. Its long half-life allows for convenient once-daily dosing in many treatment regimens.
Precautions
- Inform your doctor if you have a history of allergic reactions to Ceftriaxone, other cephalosporins, penicillins, or any other drugs.
- Use with caution in patients with a history of gastrointestinal disease, especially colitis, as it may lead to Clostridium difficile-associated diarrhea.
- Avoid concomitant use with calcium-containing intravenous solutions or products, especially in neonates, due to the risk of precipitation.
- Patients with severe renal or hepatic impairment may require dose adjustment; close monitoring is recommended.
- Prolonged use may result in overgrowth of non-susceptible organisms, requiring careful monitoring.
- Regular monitoring of blood counts and liver/kidney function tests may be advised during prolonged therapy.
Safety Advice
Alcohol
CAUTIONIt is generally advisable to avoid alcohol consumption while on Ceftriaxone treatment. Alcohol may exacerbate some side effects like nausea or dizziness, though direct interaction is not well-established.
Pregnancy
CONSULT YOUR DOCTORCEFTRACEF 1GM INJ W/W should be used during pregnancy only if clearly needed and after careful consideration of the benefits versus risks. Animal studies have not shown harm, but human data is limited. Always consult your doctor.
Breastfeeding
CONSULT YOUR DOCTORCeftriaxone is excreted in low concentrations in human milk. While generally considered compatible with breastfeeding, caution is advised. Consult your doctor to weigh the potential risks and benefits to the infant.
Driving
SAFECEFTRACEF 1GM INJ W/W is generally not known to impair the ability to drive or operate machinery. However, if you experience dizziness or other side effects that affect your concentration, avoid driving.
Kidney
CAUTIONPatients with severe kidney disease should use CEFTRACEF 1GM INJ W/W with caution. Dose adjustments may be necessary, and renal function should be closely monitored by your doctor.
Liver
CAUTIONUse CEFTRACEF 1GM INJ W/W with caution in patients with severe liver disease. Your doctor may need to adjust the dosage, and liver function should be regularly monitored during treatment.
Fact Box
Frequently asked questions by patients
Q: How quickly does CEFTRACEF 1GM INJ W/W start working?
A: CEFTRACEF 1GM INJ W/W starts working relatively quickly after administration, as it is given via injection, allowing for rapid absorption. You may start to feel better within a few days, but it's crucial to complete the full course of treatment as prescribed by your doctor.
Q: Can I stop CEFTRACEF 1GM INJ W/W if I feel better?
A: No, you should never stop CEFTRACEF 1GM INJ W/W prematurely, even if your symptoms improve. Stopping early can lead to the infection recurring and may contribute to antibiotic resistance. Always complete the full course as directed by your doctor.
Q: What if I am allergic to penicillin?
A: If you have a history of penicillin allergy, it's crucial to inform your doctor. While Ceftriaxone is a cephalosporin, there can be cross-reactivity between penicillins and cephalosporins. Your doctor will assess the risk and decide if CEFTRACEF 1GM INJ W/W is safe for you or if an alternative antibiotic is needed.
Q: Does CEFTRACEF 1GM INJ W/W interact with other medications?
A: Yes, CEFTRACEF 1GM INJ W/W can interact with certain medications, especially calcium-containing solutions, anticoagulants, and other antibiotics. Always provide your doctor with a complete list of all medications, supplements, and herbal products you are currently taking to avoid potential interactions.
Frequently Asked Questions
Q: What is CEFTRACEF 1GM INJ W/W used for?
CEFTRACEF 1GM INJ W/W is a broad-spectrum antibiotic used to treat a wide range of severe bacterial infections, including those affecting the respiratory tract, urinary tract, skin and soft tissues, bones, joints, and also conditions like meningitis and sepsis. It is typically prescribed for serious infections requiring injectable treatment.
Q: How is CEFTRACEF 1GM INJ W/W administered?
CEFTRACEF 1GM INJ W/W is administered by a healthcare professional, either intravenously (into a vein) or intramuscularly (into a muscle). The specific route and dosage depend on the type and severity of the infection, as well as the patient's age and overall health.
Q: What are the common side effects of CEFTRACEF 1GM INJ W/W?
Common side effects may include diarrhea, rash, pain or tenderness at the injection site, nausea, and vomiting. These are usually mild and temporary. If any side effect persists or worsens, or if you experience severe reactions, contact your doctor immediately.
Q: Is CEFTRACEF 1GM INJ W/W safe during pregnancy and breastfeeding?
CEFTRACEF 1GM INJ W/W should be used during pregnancy and breastfeeding only if clearly necessary and under strict medical supervision. While animal studies haven't shown harm, human data is limited. Always consult your doctor to discuss the potential risks and benefits.
Q: What precautions should I take while on CEFTRACEF 1GM INJ W/W?
Inform your doctor about any allergies, especially to antibiotics. Avoid concurrent use with calcium-containing IV solutions. Use with caution if you have kidney or liver problems, or a history of gastrointestinal issues. Complete the full course of treatment as prescribed to prevent resistance and recurrence.
Additional Information
CEFTRACEF 1GM INJ W/W, containing Ceftriaxone, stands as a vital broad-spectrum antibiotic in the fight against serious bacterial infections in India. Its efficacy against a diverse range of pathogens makes it a preferred choice for conditions requiring potent and rapid antimicrobial action, particularly in hospital settings. The injectable formulation ensures quick systemic delivery, crucial for managing severe and life-threatening infections. While highly effective, it is imperative to use CEFTRACEF 1GM INJ W/W strictly under the guidance of a qualified healthcare professional. Adherence to the prescribed dosage and duration is critical to ensure optimal treatment outcomes and to minimize the risk of antibiotic resistance. Patients should be vigilant about potential side effects and promptly report any concerns to their doctor. This medication, when used appropriately, plays a significant role in improving patient recovery and combating bacterial diseases.
