Pain Relievers

DEOCERIN-50 CAP

Prescription Required

SALT COMPOSITION

TYPE

CAPSULE

STORAGE

Store DEOCERIN-50 CAP below 25°C in a cool, dry place. Protect from direct sunlight and moisture. Keep out of reach of children and pets.

PRODUCT INTRODUCTION

DEOCERIN-50 CAP, containing Diacerein 50mg, is a vital medication specifically formulated for the management of osteoarthritis, a chronic degenerative joint disease. This capsule works by targeting the underlying processes of cartilage breakdown, offering relief from joint pain, stiffness, and improving overall joint function. As a Disease-Modifying Osteoarthritis Drug (DMOAD), DEOCERIN-50 CAP not only alleviates symptoms but also helps to slow down the progression of cartilage damage, making it a cornerstone in the long-term treatment strategy for patients in India suffering from this debilitating condition. It aims to enhance the quality of life by restoring mobility and comfort.

Uses of DEOCERIN-50 CAP

DEOCERIN-50 CAP is primarily prescribed for the effective management of osteoarthritis, a condition characterized by the breakdown of joint cartilage.

Osteoarthritis of the Knee
Used to alleviate pain, reduce stiffness, and improve functional mobility in patients with osteoarthritis affecting the knee joints. It helps in preserving the cartilage structure and slowing down disease progression, offering long-term relief.
Osteoarthritis of the Hip
Effective in managing symptoms such as chronic pain and restricted movement associated with hip osteoarthritis. DEOCERIN-50 CAP contributes to maintaining the integrity of hip joint cartilage and enhancing patient comfort.
Other Degenerative Joint Conditions
May be prescribed for other forms of degenerative joint disease where cartilage degradation is a primary concern, helping to reduce inflammation, pain, and support cartilage health in various affected joints.

Side Effects of DEOCERIN-50 CAP

Like all medicines, DEOCERIN-50 CAP can cause side effects, although not everybody gets them. Most side effects are mild and temporary.

Common side effects

Diarrhea
Abdominal pain
Nausea
Urine discoloration (yellow or brown)
Flatulence

Less common but potentially serious side effects may include:

Liver enzyme elevation
Skin rash
Pruritus (itching)

If any side effect persists or worsens, or if you experience any other unusual symptoms, please consult your doctor immediately.

How to use DEOCERIN-50 CAP

Adults:
Typically, the recommended dosage is one DEOCERIN-50 CAP (50mg) once daily for the initial 2-4 weeks to minimize gastrointestinal side effects. Following this period, the dosage may be increased to one capsule (50mg) twice daily, or as directed by your physician. It should be taken with food.
Children:
DEOCERIN-50 CAP is not recommended for use in children and adolescents below 18 years of age due to insufficient data on safety and efficacy in this population.
Elderly:
No specific dose adjustment is generally required for elderly patients, however, caution is advised, especially in those with renal impairment. Your doctor may monitor kidney function and adjust the dose if necessary.
Missed Dose:
If you miss a dose of DEOCERIN-50 CAP, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

How DEOCERIN-50 CAP works

Diacerein, the active ingredient in DEOCERIN-50 CAP, exerts its therapeutic effects primarily by inhibiting Interleukin-1 beta (IL-1β), a pro-inflammatory cytokine that plays a crucial role in the degradation of cartilage in osteoarthritis. By blocking IL-1β, Diacerein reduces the activity of enzymes like metalloproteinases and aggrecanases, which are responsible for breaking down cartilage components such as collagen and proteoglycans. This inhibitory action helps to prevent further damage to the joint cartilage. Furthermore, Diacerein also stimulates the synthesis of proteoglycans and hyaluronic acid, essential components of healthy cartilage, thereby promoting cartilage repair and regeneration. It exhibits both anti-inflammatory and analgesic properties, contributing to pain reduction and improved joint mobility. Unlike traditional NSAIDs, Diacerein acts slowly and its effects are sustained, offering a disease-modifying approach to osteoarthritis management.

Precautions

Inform your doctor if you have a history of liver disease or impaired liver function.
Use with caution in patients with kidney impairment; dose adjustment may be necessary.
Avoid use in patients with inflammatory bowel disease (Crohn's disease, ulcerative colitis).
Do not take DEOCERIN-50 CAP if you are pregnant or breastfeeding.
Monitor for gastrointestinal side effects, especially diarrhea, which is common during the initial weeks.
Avoid concomitant use with laxatives, as this may worsen diarrhea.

Safety Advice

Alcohol

CONSULT YOUR DOCTOR

It is advisable to consult your doctor regarding alcohol consumption while taking DEOCERIN-50 CAP. While there's no direct interaction, excessive alcohol intake can affect liver function, which might be a concern with certain medications.

Pregnancy

UNSAFE

DEOCERIN-50 CAP is generally not recommended during pregnancy. Animal studies have shown potential risks, and there is insufficient data on human pregnancy. Always consult your doctor before taking any medication if you are pregnant or planning a pregnancy.

Breastfeeding

UNSAFE

It is not known whether Diacerein passes into breast milk. Therefore, DEOCERIN-50 CAP is generally contraindicated during breastfeeding. Please consult your doctor to discuss alternative treatments or the risks involved.

Driving

SAFE

DEOCERIN-50 CAP is not known to affect your ability to drive or operate machinery. You can safely drive unless you experience side effects like dizziness, which are rare.

Kidney

CAUTION

Use DEOCERIN-50 CAP with caution if you have kidney disease. Dose adjustment may be necessary for patients with severe renal impairment. Regular monitoring of kidney function is recommended by your doctor.

Liver

CAUTION

Patients with pre-existing liver conditions should use DEOCERIN-50 CAP with caution. Liver function tests should be monitored periodically, especially during long-term treatment. Consult your doctor for personalized advice.

Fact Box

Chemical Class

Anthraquinone derivative

Habit Forming

Therapeutic Class

Anti-arthritic, Disease-Modifying Osteoarthritis Drug (DMOAD)

Action Class

Interleukin-1 beta inhibitor, Chondroprotective

Frequently asked questions by patients

Q: How long does DEOCERIN-50 CAP take to show its effect?

A: Diacerein acts slowly, and its full therapeutic effects, such as significant pain reduction and improved joint function, may take several weeks to a few months to become apparent. Consistent use as prescribed is crucial for optimal results.

Q: Can I take DEOCERIN-50 CAP with other pain relievers?

A: It is generally safe to take DEOCERIN-50 CAP with paracetamol. However, consult your doctor before combining it with other NSAIDs or pain relievers, as they might have different mechanisms of action and potential interactions.

Q: Is DEOCERIN-50 CAP safe for long-term use?

A: Yes, DEOCERIN-50 CAP is designed for long-term management of osteoarthritis. However, long-term use should always be under the supervision of a healthcare professional, with periodic monitoring for side effects, especially liver and kidney function.

Q: What should I do if I experience severe diarrhea?

A: Diarrhea is a common side effect, especially at the start of treatment. If you experience severe or persistent diarrhea, contact your doctor immediately. They may advise a temporary dose reduction or discontinuation.

Frequently Asked Questions

Q: What is DEOCERIN-50 CAP primarily used for?

DEOCERIN-50 CAP is primarily used for the long-term treatment of osteoarthritis, a degenerative joint disease. It helps to reduce joint pain, stiffness, and swelling, while also working to slow down the progression of cartilage damage in affected joints like the knees and hips.

Q: How does Diacerein in DEOCERIN-50 CAP work to treat osteoarthritis?

Diacerein works by inhibiting Interleukin-1 beta (IL-1β), a key inflammatory cytokine involved in cartilage degradation. This action reduces the activity of enzymes that break down cartilage and also stimulates the production of vital cartilage components, thereby protecting and potentially repairing joint tissue.

Q: What are the common side effects of DEOCERIN-50 CAP?

Common side effects include gastrointestinal issues such as diarrhea, abdominal pain, and nausea. You might also notice a harmless yellow or brown discoloration of urine. These effects are often mild and tend to subside with continued use or a dose adjustment.

Q: Can DEOCERIN-50 CAP cure osteoarthritis?

Osteoarthritis is a chronic condition with no known cure. However, DEOCERIN-50 CAP is a disease-modifying agent that helps manage symptoms, reduce pain, improve joint function, and slow down the progression of cartilage damage, significantly improving the patient's quality of life.

Q: Is it safe to take DEOCERIN-50 CAP if I have kidney problems?

If you have kidney problems, DEOCERIN-50 CAP should be used with caution, and your doctor may need to adjust the dosage, especially in cases of severe renal impairment. Regular monitoring of kidney function will be essential to ensure safe use.